GTS-21 HCL (DMXBA) Review | Everything you need to know | 2020

This is a complete guide and review of GTS-21 HCL, also known as GTS 21 or DMXBA. This nootropic is currently being extensively researched for treatment of Alzheimer’s and Schizophrenia as well as Nicotine dependence.

gts-21 review

In this guide / review you will find out everything you need to know about GTS-21, including:

  • What is GTS-21 and how does it work
  • Is GTS-21 legal in my country
  • Where to buy high-quality GTS-21 HCL
  • What are the benefits and side effects of taking GTS-21 HCL

We will answer all of these questions as well as go over other GTS-21 topics such as the half-life, dosage, safety profile, etc.

Before we being, we need to ehmphasize a clear disclaimer. The information depicted in this article is purely for informational purposes only. You should consult your physician about medications and nutritional supplements. Please contact your healthcare professional before making any changes to your lifestyle.

With that being said, let’s dive right in by first explaining what GTS-21 HCL actually is.

GTS-21 stands for the 21st chemical compound created by Gainesville and Tokushima Scientists. It’s also frequently called DMXB-A or DMXBA because it’s actually a 3-2,4-dimethoxybenzylidene anabaseine in chemistry.

More specifically, GTS-21 HCL is a selective, orally active α (alpha) 7 nicotinic acetylcholine receptor agonist

It’s a nootropic because of the nootropic and neuroprotective properties that it has like enhanced cognition.

Generally, nootropics fall into one of these three categories:

  • Dietary suplemment
  • Synthetic substances
  • Prescription drugs

GTS-21 HCL falls into the category of dietary supplement nootropics.

Currently, DMXB-A is being exntesively researched for the treatment of Alzheimer’s diseases, schizophrenia as well as nicotine dependance.

Now that we’ve explained what GTS-21 is, let’s go over the mechanism of action – how this nootropic works.

Mechanism of action

DMXBA is one of the most potent α7 agonist. It also binds to alpha 4 beta 2 subtypes but it only really activates the alpha 7 to any signifact extent.

Its main mechanism of action is activating α7 and it does that very well. As we said, it’s the most potent α7 agonist.

This process, the inhibition of the alpha 7 nicotinic receptor, mediates a release of GABA (gamma-aminobutyric acid) by hippicampal interneurons. This is the main, most important mechanism of action and it’s also the reason why GTS-21 is being extensively researched right now. Basically, this has became a new target for therapeutic internevtion in Schizophrenia.

DMXBA also attenuates pro-inflammatory cytokine production. Recent studies have also shown that GTS-21 inhibits the activities of monocyte marcophages, endothelial cells as well as the secretion of pro-inflammatory cytokines. It does all of this by regulating the JAK2-STAT3 pathways.

We will go over all of the benefits as well as possible side effects that these mechanisms of action cause. Before we do that, however, let’s quickly go over the legality of DMXBA.


Is GTS-21 legal

GTS-21 HCL is legal just like most other nootropics. As of 2020 it’s legal in every country in the world.

It’s classified and sold as a dietary supplement, which is regulated the same as foods. Foods are legally assumed “innocent” (i.e., safe) until proven guilty, so to speak.


The GTS-21 benefits are:

  • Improved memory and cognition
  • Increased alertness
  • Better mood
  • Anti-inflamatory

Side effects

The possible GTS-21 side effects are:

  • Potential side effects at high dosages (toxicity)

From the research that we have so far, we can conclude that DMXBA has almost no side effects at normal dosages. At higher dosages, however, some people may experience side effects such as headaches. At very high dosages, GTS-21 can be potentially toxic, though this has not been fully confirmed yet.

It’s worth noting, however, that people react differently to such nootropics. So if somebody has no side effects a dosage of 450mg a day, somebody else might get nausea at that dosage. Because of that, everybody should start at small dosages and work their way up.


We can safely assume that this nootropic has a half-life of around 2-3 hours. DMXBA users take it two to three times per day and they don’t experience any side effects this way.

100% accurate GTS-21 half-life has not been confirmed yet. But from the research that we have so far, we can see that it’s somewhere between 2-3 hours.

Sadly, this means that 1 dosage of GTS-21 won’t last throughout the whole day like 1 dosage of 9-Me-BC would, for example.

In other words, this means that GTS-21 users should split their dosage into three parts and take the first in the morning, the second during lunch and the third in the afternoon. This way, DMXBA users manage to keep GTS-21 effects througout the whole day.


This study that followed 18 healthy male volunteers which were randomly put on either placebo or GTS-21 HCL.

The volunteers were taking 450mg of DMXBA (GTS-21 HCL) daily. Keep in mind that because of the half-life, they were actually taking 150mg dosages three times per day.

Basically, the study showed very promising results. The dosage of 450mg a day was very well tolerated and it didn’t show any concering side effects.

So to summarize, 450mg a day is a great dosage. A lot of users use this dosage and it’s also the dosage that was used in some human trials with very promising results.

Where to buy GTS-21 HCL

The bad thing about this nootropic is that it can be sometimes hard to find. What I mean by that is that it’s hard to buy real, high-quality GTS-21 online.

Luckily, is selling it. In fact, most DMXBA users buy it from them. I also speak from my personal experience here. Their nootropics are one of the most pure on the market right now.

You can use the code sarmguide10 to get 10% off when buying from This is the biggest discount code as of right now.


In conclusion, GTS-21-HCL is a very well rounded nootropic. A lot of its users claim that it’s the most well rounded nootropic, even more so than the racetams. It’s currently being extensively research to treat diseases such as Schizophrenia, Alzheimers and nicotine dependance.

GTS-21, also called DMXBA, also has a very good safety profile. Human trials have shown that it’s a well tolerated nootropic without any concerning side effects. The dosages they used were 450mg a day. Keep in mind that because the half-life of GTS-21-HCL is around 3 hours, it needs to be split into three dosages. So in the case of those human trials, they were actually taking GTS-21 three times a day for 150mg, all of that together added up to 450mg a day.

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