This is a complete guide and review of Oleoylethanolamide, also known as OEA.
A lot of users love it because of how similar to Modafinil this nootropic is. Some users actually get identical effects from these two. The great this about 9-Fluorenol is that it’s very affordable, unlike Modafinil.
Let’s get started.
In this guide / review, you will find out everything you need to know about Hydrafinil, including:
- What is Oleoylethanolamide
- Mechanism of action
- Is it FDA approved
- Where to buy high-quality, pure Oleoylethanolamide
- What are the benefits and side effects
We will answer all of these questions as well as go over other Oleoylethanolamide topics such as the half-life, dosages, safety profile and more.
Before we begin, we need to ehmphasize a clear disclaimer. The information depicted in this article is purely for informational purposes only. You should consult your physician about medications and nutritional supplements. Please contact your healthcare professional before making any changes to your lifestyle.
With that being said, let’s dive right in.
Oleoylethanolamide is a molecule formed in the small intestine which helps to regulate body fat, via PPAR by binding to the alpha receptor. More specificall, Oleoylethanolamide is a endogenous peroxisome proliferator-activated receptor alpha (PPAR-α) agonist.
Binding activates the peroxisome proliferator, thereby accelerating the breakdown of food in the body and giving the brain the feeling that you are full.
It’s also called frequently called OEA, or N-Oleoylethanolamide (N-Oleoylethanolamide is distinguished from Oleoylethanolamide by small changes in the chemical formula, but it is essentially the same raw material that manages the same tasks).
Oleoylethanolamide is present in vertebrates and is used in the food industry.
How does it work
Oleoylethanolamide has two mechanisms of action.
- Stimulating the brain circuit of histamine, homeostatic oxytocin and hedonic dopamine pathways in the brain
- Increased production of PPARs (Peroxisome proliferator-activated receptors)
In the mechanism of action, it stimulates the feeling of hunger by stimulating the brain circuit of histamine, homeostatic oxytocin, and hedonic dopamine pathways in the brain. In the long run, this contributes to reduced food intake.
In the second mechanism of action, Oleoylethanolamide stimulates the production of PPARs in the human body. PPAR is found in the body in the small intestine and is involved in the breakdown of food, especially fat. It gives your brain such a feeling that you are full.
The benefits of Oleoylethanolamide are:
- Preventing neurotranmission
- Assistance in the operation of the human mechanisms
- Reduced appetite
- Reduced stress levels – reduced anxiety
- Accelerates the breakdown of food and reduces body weight
- Regulates the action of hormones
- Improves pancreas function
- Lower chance of Parkinson’s disease
Preventing Neurotranmission and more effective human mechanisms
As I said before, Oleoylethanolamide activates PPARα through the hormone oxytocin in the body. PPAR is also present in the small intestine, and by activating this appetite we do not only temporarily stop or suppress hunger, but we permanently reduce the feeling of hunger. Oral ingestion of Oleoylethanolamide (10 mg / kg) reduced their food intake by 15.5% in a rat study 90 minutes after ingestion. A 28-day study performed on mice also showed that Oleoylethanolamide reduced stress levels after only 7 days. PPAR in the body also increases the level of β3-adrenergic receptors, which positively help the body to lose fat.
Reduced body weight and stress
As I said before, Oleoylethanolamide activates PPARα through the hormone oxytocin in the body. PPAR is also present in the small intestine, and by activating this appetite we do not only temporarily stop or suppress hunger, but we permanently reduce the feeling of hunger. Oral ingestion of Oleoylethanolamide (10 mg / kg) reduced their food intake by 15.5% in a rat study 90 minutes after ingestion. A 28-day study performed on mice also showed that Oleoylethanolamide reduced stress levels after only 7 days.
Better hormone and pancreas function
Ghrelin, contained in Oleoylethanolamide, reduced the appetite of test subjects by between 40-50% in a study performed on rats.
By activating the GPR119 fat receptor in the pancreas, Oleoylethanolamide enables greater release of the GLP-1 hormone. The hormone GLP-1 in the pancreas also accelerates the release of other hormones.
Research suggests that Oleoylethanolamide via PPAR also reduces the possibility of Parkinson’s disease, but this has not yet been confirmed.
A study by the US Food and Drug Administration (FDA) did not detect any side effects of taking Oleoylethanolamide in all of its testing.
In 2015, the FDA approved Oleoylethanolamide (OEA) as a dietary supplement. This suggests, that according to the FDA, OEA has no threatning side effects when taken in normal dosages.
The exact Oleoylethanolamide half-life isn’t completely clear but the scientists generally agree that it’s somewhere between 15-24 hours.
Because of this, it’s safest to assume that it has a 24 hour half-life. This is why almost all users take it once every 24 hours.
Studies have shown that oleoylethanolamide works best at 10mg / kg. According to the recommendations, a 150 lb person should consume 100 mg, a 200 lb person 145mg and a 250 lb person 180 mg Oleoylethanolamide. It should be taken daily 30 minutes before dinner or breakfast.
Where to buy Oleoylethanolamide
Science.bio is currently the most legitimate and reliable Oleoylethanolamide supplier.
In conclusion, Oleoylethanolamide is a very promising compound.